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Sarcoidosis with prominent giant cells

Identifieur interne : 002326 ( Main/Exploration ); précédent : 002325; suivant : 002327

Sarcoidosis with prominent giant cells

Auteurs : Catherine Drummond ; Elliott Savdie [Australie] ; Steven Kossard

Source :

RBID : ISTEX:F39D5D1BEE933E42469A08EBCDEBECE617AFD2DB

English descriptors

Abstract

A 31‐year‐old man presented with a widespread papular eruption and systemic symptoms including renal colic and decreased exercise tolerance. The combination of clinical features and laboratory investigations that revealed an elevated angiotensin converting enzyme level and hypercalcaemia enabled a diagnosis of sarcoidosis to be made. Multiple skin biopsies showed prominent Touton‐like giant cells which delayed the diagnosis. Giant cells are frequently seen in sarcoidal granulomas but in some cases their prominence and Touton‐like appearance may suggest alternative diagnoses such as xanthogranulomas.

Url:
DOI: 10.1046/j.1440-0960.2001.00539.x


Affiliations:


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Le document en format XML

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<term>Catherine drummond</term>
<term>Clinical features</term>
<term>Deep dermis</term>
<term>Dermis</term>
<term>Disseminatum</term>
<term>Drummond</term>
<term>Evident necrobiosis</term>
<term>Exercise tolerance</term>
<term>Foreign bodies</term>
<term>Frank xanthomatous features</term>
<term>Giant cells</term>
<term>Granuloma</term>
<term>Granuloma annulare</term>
<term>Histiocyte</term>
<term>Histiocytic</term>
<term>Histiocytic syndromes</term>
<term>Hypercalcaemia</term>
<term>Juvenile xanthogranuloma</term>
<term>Lesion</term>
<term>Lymphocytes figure</term>
<term>Martin dunitz</term>
<term>Month history</term>
<term>Multinucleated histiocytes</term>
<term>Multiple biopsies</term>
<term>Multiple skin biopsies</term>
<term>Normal range</term>
<term>Papular</term>
<term>Papular skin eruption</term>
<term>Papule</term>
<term>Plasma cells</term>
<term>Prednisolone</term>
<term>Prednisolone dosage</term>
<term>Prominent feature</term>
<term>Prominent giant cell component</term>
<term>Prominent giant cells</term>
<term>Renal</term>
<term>Renal colic</term>
<term>Sarcoidal</term>
<term>Sarcoidal granulomas</term>
<term>Sarcoidosis</term>
<term>Skin biopsies</term>
<term>Skin lesions</term>
<term>Systemic involvement</term>
<term>Systemic symptoms</term>
<term>Text atlas</term>
<term>Touton</term>
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<term>Widespread papular eruption</term>
<term>Xanthogranuloma</term>
<term>Xanthoma</term>
<term>Xanthoma disseminatum</term>
<term>Xanthomatous</term>
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<div type="abstract" xml:lang="en">A 31‐year‐old man presented with a widespread papular eruption and systemic symptoms including renal colic and decreased exercise tolerance. The combination of clinical features and laboratory investigations that revealed an elevated angiotensin converting enzyme level and hypercalcaemia enabled a diagnosis of sarcoidosis to be made. Multiple skin biopsies showed prominent Touton‐like giant cells which delayed the diagnosis. Giant cells are frequently seen in sarcoidal granulomas but in some cases their prominence and Touton‐like appearance may suggest alternative diagnoses such as xanthogranulomas.</div>
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