Sarcoidosis with prominent giant cells
Identifieur interne : 002326 ( Main/Exploration ); précédent : 002325; suivant : 002327Sarcoidosis with prominent giant cells
Auteurs : Catherine Drummond ; Elliott Savdie [Australie] ; Steven KossardSource :
- Australasian Journal of Dermatology [ 0004-8380 ] ; 2001-11.
English descriptors
- Teeft :
- Annulare, Biopsy, Catherine drummond, Clinical features, Deep dermis, Dermis, Disseminatum, Drummond, Evident necrobiosis, Exercise tolerance, Foreign bodies, Frank xanthomatous features, Giant cells, Granuloma, Granuloma annulare, Histiocyte, Histiocytic, Histiocytic syndromes, Hypercalcaemia, Juvenile xanthogranuloma, Lesion, Lymphocytes figure, Martin dunitz, Month history, Multinucleated histiocytes, Multiple biopsies, Multiple skin biopsies, Normal range, Papular, Papular skin eruption, Papule, Plasma cells, Prednisolone, Prednisolone dosage, Prominent feature, Prominent giant cell component, Prominent giant cells, Renal, Renal colic, Sarcoidal, Sarcoidal granulomas, Sarcoidosis, Skin biopsies, Skin lesions, Systemic involvement, Systemic symptoms, Text atlas, Touton, True touton cells, Widespread papular eruption, Xanthogranuloma, Xanthoma, Xanthoma disseminatum, Xanthomatous.
Abstract
A 31‐year‐old man presented with a widespread papular eruption and systemic symptoms including renal colic and decreased exercise tolerance. The combination of clinical features and laboratory investigations that revealed an elevated angiotensin converting enzyme level and hypercalcaemia enabled a diagnosis of sarcoidosis to be made. Multiple skin biopsies showed prominent Touton‐like giant cells which delayed the diagnosis. Giant cells are frequently seen in sarcoidal granulomas but in some cases their prominence and Touton‐like appearance may suggest alternative diagnoses such as xanthogranulomas.
Url:
DOI: 10.1046/j.1440-0960.2001.00539.x
Affiliations:
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Le document en format XML
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<term>Dermis</term>
<term>Disseminatum</term>
<term>Drummond</term>
<term>Evident necrobiosis</term>
<term>Exercise tolerance</term>
<term>Foreign bodies</term>
<term>Frank xanthomatous features</term>
<term>Giant cells</term>
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<term>Histiocytic syndromes</term>
<term>Hypercalcaemia</term>
<term>Juvenile xanthogranuloma</term>
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<term>Lymphocytes figure</term>
<term>Martin dunitz</term>
<term>Month history</term>
<term>Multinucleated histiocytes</term>
<term>Multiple biopsies</term>
<term>Multiple skin biopsies</term>
<term>Normal range</term>
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<term>Papular skin eruption</term>
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<term>Prednisolone</term>
<term>Prednisolone dosage</term>
<term>Prominent feature</term>
<term>Prominent giant cell component</term>
<term>Prominent giant cells</term>
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<term>Text atlas</term>
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<front><div type="abstract" xml:lang="en">A 31‐year‐old man presented with a widespread papular eruption and systemic symptoms including renal colic and decreased exercise tolerance. The combination of clinical features and laboratory investigations that revealed an elevated angiotensin converting enzyme level and hypercalcaemia enabled a diagnosis of sarcoidosis to be made. Multiple skin biopsies showed prominent Touton‐like giant cells which delayed the diagnosis. Giant cells are frequently seen in sarcoidal granulomas but in some cases their prominence and Touton‐like appearance may suggest alternative diagnoses such as xanthogranulomas.</div>
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